解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knoc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111322
更新日期:2020-11-07 00:00:00
abstract::The Muraenidae is one of the largest and most complex anguilliform families. Despite their abundance and important ecological roles, morays are little studied, especially cytogenetically, and both their phylogenetic relationships and the taxonomy of their genera are controversial. With the aim of extending the karyolo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111319
更新日期:2020-11-06 00:00:00
abstract::Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111314
更新日期:2020-11-05 00:00:00
abstract::Multidrug-resistant (MDR; resistance to >3 antimicrobial classes) Salmonella enterica serovar I 4,[5],12:i:- strains were linked to a 2015 foodborne outbreak from pork. Strain USDA15WA-1, associated with the outbreak, harbors an MDR module and the metal tolerance element Salmonella Genomic Island 4 (SGI-4). Characteri...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111291
更新日期:2020-10-30 00:00:00
abstract::The performance of genomic prediction (GP) on genetically correlated traits can be improved through an interdependence multi-trait model under a multi-environment context. In this study, a panel of 237 soft facultative wheat (Triticumaestivum L.) lines was evaluated to compare single- and multi-trait models for predic...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111270
更新日期:2020-10-28 00:00:00
abstract::Hexokinase (HK) is a key enzyme in chitin biosynthesis in insects and plays an important role in development and energy regulation. It also performs a crucial role in the synthesis of Glucose-6-phosphate and its putative functions are studied via injection of dsRNA corresponding to the hexokinase gene from Cnaphalocro...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111258
更新日期:2020-10-26 00:00:00
abstract::Prader-Willi syndrome (PWS) is a complex multisystemic condition caused by a lack of paternal expression of imprinted genes from the 15q11.2-q13 region. Limited literature exists on the association between molecular classes, growth hormone use, and the prevalence of psychiatric phenotypes in PWS. In this study, we ana...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111250
更新日期:2020-10-23 00:00:00
abstract::We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotatio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111236
更新日期:2020-10-22 00:00:00
abstract::The genus Lactobacillus includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on h...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101234
更新日期:2020-10-21 00:00:00
abstract::In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skele...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101228
更新日期:2020-10-20 00:00:00
abstract::Genetic dissection of yield components and seed mineral-nutrient is crucial for understanding plant physiological and biochemical processes and alleviate nutrient malnutrition. Sesame (Sesamum indicum L.) is an orphan crop that harbors rich allelic repertoire for seed mineral-nutrients. Here, we harness this wide dive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101221
更新日期:2020-10-18 00:00:00
abstract::Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101201
更新日期:2020-10-15 00:00:00
abstract::The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101192
更新日期:2020-10-14 00:00:00
abstract::The wall-associated kinase (WAK) and wall-associated kinase like (WAKL) is a subfamily of receptor-like kinases associated with the cell wall, which have been suggested as sensors of the extracellular environment and triggers of intracellular signals. However, these proteins have not yet been comprehensively analyzed ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101186
更新日期:2020-10-12 00:00:00
abstract::A 9-month old male Jack Russell Terrier started showing paraparesis of the hindlimbs after a walk. Hospitalized, the dog went into cardiac arrest, and later died. Necroscopic examination revealed a severe thickness of the diaphragm, esophagus, and base of the tongue, leading to the diagnosis of muscular dystrophy. The...
journal_title:Genes
pub_type:
doi:10.3390/genes11101175
更新日期:2020-10-08 00:00:00
abstract::The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101128
更新日期:2020-09-25 00:00:00
abstract::Chlorella is a popular microalga with robust physiological and biochemical characteristics, which can be cultured under various conditions. The exploration of the small RNA content of Chlorella could improve strategies for the enhancement of metabolite production from this microalga. In this study, stress was introduc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101131
更新日期:2020-09-25 00:00:00
abstract::The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101123
更新日期:2020-09-24 00:00:00
abstract::Propionibacteria have been studied extensively since the early 1930s due to their relevance to industry and importance as human pathogens. Still, their unique metabolism is far from fully understood. This is partly due to their signature high GC content, which has previously hampered the acquisition of quality sequenc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101115
更新日期:2020-09-23 00:00:00
abstract::Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level using both Illumina and nanopore 16S rRNA gene sequencing. We also monitored the progression of n...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091105
更新日期:2020-09-21 00:00:00
abstract::Despite the extensive research conducted in recent decades, the molecular mechanisms underlying major depressive disorder (MDD) and relative evidence-based treatments remain unclear. Various hypotheses have been successively proposed, involving different biological systems. This narrative review aims to critically ill...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11091089
更新日期:2020-09-18 00:00:00
abstract:BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091072
更新日期:2020-09-12 00:00:00
abstract::Smoltification and early seawater phase are critical developmental periods with physiological and biochemical changes in Atlantic salmon that facilitates survival in saltwater. MicroRNAs (miRNAs) are known to have important roles in development, but whether any miRNAs are involved in regulation of gene expression duri...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091059
更新日期:2020-09-08 00:00:00
abstract::The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091052
更新日期:2020-09-07 00:00:00
abstract::Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events. Various processes are known to allow a gene to be duplicated and different models explain how duplica...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11091046
更新日期:2020-09-04 00:00:00
abstract::In domesticated strains of the Nile tilapia, phenotypic sex has been linked to genetic variants on linkage groups 1, 20 and 23. This diversity of sex-loci might reflect a naturally polymorphic sex determination system in Nile tilapia, or it might be an artefact arising from the process of domestication. Here, we searc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091017
更新日期:2020-08-29 00:00:00
abstract::PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091012
更新日期:2020-08-27 00:00:00
abstract::As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091003
更新日期:2020-08-26 00:00:00
abstract::Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11090995
更新日期:2020-08-25 00:00:00
abstract::Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090984
更新日期:2020-08-24 00:00:00
abstract::We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090978
更新日期:2020-08-22 00:00:00
abstract::Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alte...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090960
更新日期:2020-08-20 00:00:00
abstract::We set out to assess the NIH/3T3 cell proliferation activity of Arabidopsis oil body-expressed recombinant oleosin-hEGF-hEGF protein. Normally, human epidermal growth factor (hEGF) is purified through complex process, however, oleosin fusion technology provides an inexpensive and scalable platform for its purification...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090959
更新日期:2020-08-19 00:00:00
abstract::At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11080902
更新日期:2020-08-07 00:00:00
abstract::Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11080907
更新日期:2020-08-07 00:00:00
abstract::Genome wide association studies (GWAS) are a well established methodology to identify genomic variants and genes that are responsible for traits of interest in all branches of the life sciences. Despite the long time this methodology has had to mature the reliable detection of genotype-phenotype associations is still ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080892
更新日期:2020-08-05 00:00:00
abstract::Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11080871
更新日期:2020-07-31 00:00:00
abstract::The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11080875
更新日期:2020-07-31 00:00:00
abstract::Excessive fat deposition in the hepatocytes, associated with excess dietary fat intake, was related to the occurrence of fatty livers in fish. miR-101b plays the important roles in controlling lipid metabolism, but the underlying mechanism at the post-transcriptional level remains unclear. The purpose of this study is...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080861
更新日期:2020-07-29 00:00:00
abstract::(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080858
更新日期:2020-07-27 00:00:00